Paracetamol, also known as acetaminophen, is one of the most widely used medications worldwide for pain relief and fever reduction., Aim of the Work: The aim of this study is to determine the effect and ability of paracetamol to cause fetal malformations in pregnant rats., Materials and Methods: The study included (36) of pregnant rats, divided into three groups, the first group doses the set of control with distilled water only, the second group doses the drug of paracetamol 250 mg/kg, the third group died with the drug paracetamol 350 mg/kg of body weight from the first day to twenty days of pregnancy., Results: The results of the current study showed that the length of the skull, vertebral column, front limbs, and hind limbs of fetuses at 20 days of gestation from the group treated with paracetamol at doses of 250 and 350 mg/kg of body weight showed a significant decrease (P<0.05) compared to the control group. The results of the statistical analysis showed a significant decrease (P<0.05) in calcium, phosphorus, sodium and potassium concentration in the two groups of pregnant mothers treated with paracetamol 250 and 350 mg/kg at the stages of pregnancy (10, 15 and 20) compared to the control group. Histological examination of the kidneys of newborns treated with paracetamol 250 and 350 mg/kg immediately after birth showed clear pathological effects compared with the control group., Conclusion: The results indicate that paracetamol is unsafe for use during pregnancy.